Mindanao tells the story of Muslim woman Saima Datupalo (Judy Ann Santos). While taking care of her cancer-stricken daughter named Aisa Datupalo (Yuna Tangog) in a temporary home for children with cancer called the House of Hope in Davao, her soldier husband Malang Datupalo (Allen Dizon), a combat medic, is an offensive operation in Maguindanao.